Mpox Response in Guinea-Bissau: Guinea-Bissau confirmed its first mpox case, triggering national response mechanisms under WHO International Health Regulations. Health workers collected samples from a 27-year-old woman and sent them for lab testing at Guinea-Bissau’s National Institute of Public Health and then to Institut Pasteur in Dakar for confirmation. Authorities have launched contact tracing, reinforced surveillance at borders, and urged the public to watch for fever or skin rashes while following basic prevention steps like frequent handwashing. Early Grade Teaching Pilot: Guinea-Bissau is piloting a structured pedagogy model in early grades through the World Bank’s Guinea-Bissau Human Capital Project, with 25 schools benefiting from sequenced lesson plans and learning materials to strengthen Portuguese and math teaching. Regional Security Tech Angle: Nigeria and Guinea-Bissau are deepening defence cooperation as West African militaries push for a unified front against transnational threats, including high-level talks and a continental land forces forum. Food Systems Science: A regional fisheries plan backed by FAO aims to turn science into action for small pelagic fisheries, highlighting cross-border management needs for sardinella and bonga that support coastal and inland livelihoods.